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human dsg2 protein  (Biorbyt)


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    Structured Review

    Biorbyt human dsg2 protein
    Desmosome proteins detected in serum following SARS-CoV-2 infection. Detection of ( A ) desmoplakin (DSP, *** P = 0.0004), ( B ) junction plakoglobin (JUP), and ( C ) <t>desmoglein</t> <t>2</t> <t>(DSG2,</t> ** P = 0.0051) protein by ELISA. Results are expressed as median concentration with interquartile range, and all groups are statistically not significant from healthy controls unless annotated.
    Human Dsg2 Protein, supplied by Biorbyt, used in various techniques. Bioz Stars score: 91/100, based on 2 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/human dsg2 protein/product/Biorbyt
    Average 91 stars, based on 2 article reviews
    human dsg2 protein - by Bioz Stars, 2026-02
    91/100 stars

    Images

    1) Product Images from "SARS-CoV-2 infection is associated with anti-desmoglein 2 autoantibody detection"

    Article Title: SARS-CoV-2 infection is associated with anti-desmoglein 2 autoantibody detection

    Journal: Clinical and Experimental Immunology

    doi: 10.1093/cei/uxad046

    Desmosome proteins detected in serum following SARS-CoV-2 infection. Detection of ( A ) desmoplakin (DSP, *** P = 0.0004), ( B ) junction plakoglobin (JUP), and ( C ) desmoglein 2 (DSG2, ** P = 0.0051) protein by ELISA. Results are expressed as median concentration with interquartile range, and all groups are statistically not significant from healthy controls unless annotated.
    Figure Legend Snippet: Desmosome proteins detected in serum following SARS-CoV-2 infection. Detection of ( A ) desmoplakin (DSP, *** P = 0.0004), ( B ) junction plakoglobin (JUP), and ( C ) desmoglein 2 (DSG2, ** P = 0.0051) protein by ELISA. Results are expressed as median concentration with interquartile range, and all groups are statistically not significant from healthy controls unless annotated.

    Techniques Used: Infection, Enzyme-linked Immunosorbent Assay, Concentration Assay

    Desmoglein 2 IgG autoantibody concentrations are higher in patients post-severe SARS-CoV-2 infection. Detection of desmoglein 2 autoantibodies in COVID-19 cohorts by ELISA; convalescent COVID Intensive therapy unit (ITU), acute COVID ITU, and mild COVID convalescent, compared with non-COVID control cohorts; non-COVID ITU, Influenza (flu) ITU, and healthy controls ( N = 252, P < 0.0001). The flu ITU, non-COVID ITU, and mild COVID convalescent cohorts were all not statistically significant compared to healthy controls. Results are expressed as median OD (optical density) with interquartile range. Figure in brackets indicates number of sera per group. **** indicates a significant difference between groups at a P value of <0.0001.
    Figure Legend Snippet: Desmoglein 2 IgG autoantibody concentrations are higher in patients post-severe SARS-CoV-2 infection. Detection of desmoglein 2 autoantibodies in COVID-19 cohorts by ELISA; convalescent COVID Intensive therapy unit (ITU), acute COVID ITU, and mild COVID convalescent, compared with non-COVID control cohorts; non-COVID ITU, Influenza (flu) ITU, and healthy controls ( N = 252, P < 0.0001). The flu ITU, non-COVID ITU, and mild COVID convalescent cohorts were all not statistically significant compared to healthy controls. Results are expressed as median OD (optical density) with interquartile range. Figure in brackets indicates number of sera per group. **** indicates a significant difference between groups at a P value of <0.0001.

    Techniques Used: Infection, Enzyme-linked Immunosorbent Assay, Control

    Immunohistochemical staining of post-mortem cardiac tissue. ( A ) Non-COVID-19 post-mortem heart tissue shows uniform single-banded staining for DSG2 corresponding to the site of intercalated discs (these are indicated by black arrows). ( B ) Cardiac muscle from COVID-19 post-mortem cases showed areas of single and notable double banded staining for DSG2 (arrowed). ( C ) Post-mortem heart tissue from a non-COVID-19 patient stained for IgG deposition. ( D ) Post-mortem heart tissue from a COVID-19 patient demonstrating IgG deposition at intercalated discs. Images representative of 3 hearts from non-COVID-19 patients and 8 patients who died from COVID-19.
    Figure Legend Snippet: Immunohistochemical staining of post-mortem cardiac tissue. ( A ) Non-COVID-19 post-mortem heart tissue shows uniform single-banded staining for DSG2 corresponding to the site of intercalated discs (these are indicated by black arrows). ( B ) Cardiac muscle from COVID-19 post-mortem cases showed areas of single and notable double banded staining for DSG2 (arrowed). ( C ) Post-mortem heart tissue from a non-COVID-19 patient stained for IgG deposition. ( D ) Post-mortem heart tissue from a COVID-19 patient demonstrating IgG deposition at intercalated discs. Images representative of 3 hearts from non-COVID-19 patients and 8 patients who died from COVID-19.

    Techniques Used: Immunohistochemical staining, Staining



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    Desmosome proteins detected in serum following SARS-CoV-2 infection. Detection of ( A ) desmoplakin (DSP, *** P = 0.0004), ( B ) junction plakoglobin (JUP), and ( C ) <t>desmoglein</t> <t>2</t> <t>(DSG2,</t> ** P = 0.0051) protein by ELISA. Results are expressed as median concentration with interquartile range, and all groups are statistically not significant from healthy controls unless annotated.
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    Image Search Results


    Desmosome proteins detected in serum following SARS-CoV-2 infection. Detection of ( A ) desmoplakin (DSP, *** P = 0.0004), ( B ) junction plakoglobin (JUP), and ( C ) desmoglein 2 (DSG2, ** P = 0.0051) protein by ELISA. Results are expressed as median concentration with interquartile range, and all groups are statistically not significant from healthy controls unless annotated.

    Journal: Clinical and Experimental Immunology

    Article Title: SARS-CoV-2 infection is associated with anti-desmoglein 2 autoantibody detection

    doi: 10.1093/cei/uxad046

    Figure Lengend Snippet: Desmosome proteins detected in serum following SARS-CoV-2 infection. Detection of ( A ) desmoplakin (DSP, *** P = 0.0004), ( B ) junction plakoglobin (JUP), and ( C ) desmoglein 2 (DSG2, ** P = 0.0051) protein by ELISA. Results are expressed as median concentration with interquartile range, and all groups are statistically not significant from healthy controls unless annotated.

    Article Snippet: Human DSG2 protein (Biorbyt, UK; REF: orb624074) was diluted to a concentration of 1 μg/ml in Dulbecco’s PBS and 50 μl diluted antigen added to each well of a 96-well plate.

    Techniques: Infection, Enzyme-linked Immunosorbent Assay, Concentration Assay

    Desmoglein 2 IgG autoantibody concentrations are higher in patients post-severe SARS-CoV-2 infection. Detection of desmoglein 2 autoantibodies in COVID-19 cohorts by ELISA; convalescent COVID Intensive therapy unit (ITU), acute COVID ITU, and mild COVID convalescent, compared with non-COVID control cohorts; non-COVID ITU, Influenza (flu) ITU, and healthy controls ( N = 252, P < 0.0001). The flu ITU, non-COVID ITU, and mild COVID convalescent cohorts were all not statistically significant compared to healthy controls. Results are expressed as median OD (optical density) with interquartile range. Figure in brackets indicates number of sera per group. **** indicates a significant difference between groups at a P value of <0.0001.

    Journal: Clinical and Experimental Immunology

    Article Title: SARS-CoV-2 infection is associated with anti-desmoglein 2 autoantibody detection

    doi: 10.1093/cei/uxad046

    Figure Lengend Snippet: Desmoglein 2 IgG autoantibody concentrations are higher in patients post-severe SARS-CoV-2 infection. Detection of desmoglein 2 autoantibodies in COVID-19 cohorts by ELISA; convalescent COVID Intensive therapy unit (ITU), acute COVID ITU, and mild COVID convalescent, compared with non-COVID control cohorts; non-COVID ITU, Influenza (flu) ITU, and healthy controls ( N = 252, P < 0.0001). The flu ITU, non-COVID ITU, and mild COVID convalescent cohorts were all not statistically significant compared to healthy controls. Results are expressed as median OD (optical density) with interquartile range. Figure in brackets indicates number of sera per group. **** indicates a significant difference between groups at a P value of <0.0001.

    Article Snippet: Human DSG2 protein (Biorbyt, UK; REF: orb624074) was diluted to a concentration of 1 μg/ml in Dulbecco’s PBS and 50 μl diluted antigen added to each well of a 96-well plate.

    Techniques: Infection, Enzyme-linked Immunosorbent Assay, Control

    Immunohistochemical staining of post-mortem cardiac tissue. ( A ) Non-COVID-19 post-mortem heart tissue shows uniform single-banded staining for DSG2 corresponding to the site of intercalated discs (these are indicated by black arrows). ( B ) Cardiac muscle from COVID-19 post-mortem cases showed areas of single and notable double banded staining for DSG2 (arrowed). ( C ) Post-mortem heart tissue from a non-COVID-19 patient stained for IgG deposition. ( D ) Post-mortem heart tissue from a COVID-19 patient demonstrating IgG deposition at intercalated discs. Images representative of 3 hearts from non-COVID-19 patients and 8 patients who died from COVID-19.

    Journal: Clinical and Experimental Immunology

    Article Title: SARS-CoV-2 infection is associated with anti-desmoglein 2 autoantibody detection

    doi: 10.1093/cei/uxad046

    Figure Lengend Snippet: Immunohistochemical staining of post-mortem cardiac tissue. ( A ) Non-COVID-19 post-mortem heart tissue shows uniform single-banded staining for DSG2 corresponding to the site of intercalated discs (these are indicated by black arrows). ( B ) Cardiac muscle from COVID-19 post-mortem cases showed areas of single and notable double banded staining for DSG2 (arrowed). ( C ) Post-mortem heart tissue from a non-COVID-19 patient stained for IgG deposition. ( D ) Post-mortem heart tissue from a COVID-19 patient demonstrating IgG deposition at intercalated discs. Images representative of 3 hearts from non-COVID-19 patients and 8 patients who died from COVID-19.

    Article Snippet: Human DSG2 protein (Biorbyt, UK; REF: orb624074) was diluted to a concentration of 1 μg/ml in Dulbecco’s PBS and 50 μl diluted antigen added to each well of a 96-well plate.

    Techniques: Immunohistochemical staining, Staining